abstract：:Commensal enteric bacteria stimulate innate immune cells and increase numbers of lamina propria and mesenteric lymph node (MLN) T and B lymphocytes. However, the influence of luminal bacteria on acquired immune function is not understood fully. We investigated the effects of intestinal bacterial colonization on T cell...

journal_title：Clinical and experimental immunology

authors： Walton KL,Galanko JA,Balfour Sartor R,Fisher NC

更新日期：2006-03-01 00:00:00

abstract：:The family of Toll-like receptors (TLRs) initiates innate immune responses, and Toll-like receptor 4 (TLR4) was considered to be an important player in the initiation and progression of atherosclerotic disease. The aim of the study was to investigate the expression of TLR4 on peripheral-blood mononuclear cells (PBMCs)...

journal_title：Clinical and experimental immunology

authors： Geng HL,Lu HQ,Zhang LZ,Zhang H,Zhou L,Wang H,Zhong RQ

更新日期：2006-02-01 00:00:00

abstract：:During the innate immune response against infections, Natural Killer (NK) cells are as important effector cells as are Cytotoxic T lymphocytes (CTL) generated after antigenic stimulation in the adaptative response. NK cells increase in numbers, after viral infection or vaccination. We investigated the NK cell and CD8 ...

journal_title：Clinical and experimental immunology

authors： Azeredo EL,De Oliveira-Pinto LM,Zagne SM,Cerqueira DI,Nogueira RM,Kubelka CF

更新日期：2006-02-01 00:00:00

abstract：:The c-Jun N-terminal kinase (JNK) participates in intracellular signalling cascades that mediate inflammatory responses. Therefore, the JNK signalling may be involved in gastric injury and inhibition of this pathway may form the basis of a new strategy for the treatment of gastric injury. The aim of this study was to ...

journal_title：Clinical and experimental immunology

authors： Mitsuyama K,Tsuruta O,Matsui Y,Harada K,Tomiyasu N,Suzuki A,Takaki K,Masuda J,Handa K,Satoh Y,Bennett BL,Toyonaga A,Sata M

更新日期：2006-01-01 00:00:00

abstract：:We have reported previously that Lactobacillus casei ssp. casei, together with specific substrate dextran, exhibited an adjuvant effect of stimulating humoral immune responses against bovine serum albumin (BSA) as a model antigen in BALB/c mice. In the present study, among the Lactobacillus species tested, L. casei ss...

journal_title：Clinical and experimental immunology

authors： Ogawa T,Asai Y,Tamai R,Makimura Y,Sakamoto H,Hashikawa S,Yasuda K

更新日期：2006-01-01 00:00:00

abstract：:Summary Herpes simplex virus (HSV) represents a smart pathogen, which displays both lytic and latent modes of interaction with its natural human host. In order to be optimally equipped for immune evasion and to reply to any attacks of the host during reactivation, HSV has developed a multitude of cleverly devised defe...

journal_title：Clinical and experimental immunology

authors： Novak N,Peng WM

更新日期：2005-12-01 00:00:00

abstract：:Macrophages play a central role in inflammation and host defence against microorganisms, but they also participate actively in the resolution of inflammation after alternative activation. However, it is not known whether the resolution of inflammation requires alternative activation of new resting monocytes/macrophage...

journal_title：Clinical and experimental immunology

authors： Porcheray F,Viaud S,Rimaniol AC,Léone C,Samah B,Dereuddre-Bosquet N,Dormont D,Gras G

更新日期：2005-12-01 00:00:00

abstract：:Recent evidence has suggested that IgA1-containing macromolecules and the glycosylation of IgA1 in sera from patients with IgAN might involve the pathogenesis of IgAN. However, whether the different histological phenotypes can be attributed or not to the aberrant glycosylation of macromolecular IgA1 has not yet been e...

journal_title：Clinical and experimental immunology

authors： Xu LX,Yan Y,Zhang JJ,Zhang Y,Zhao MH

更新日期：2005-12-01 00:00:00

abstract：:Aspergillus fumigatus (Af) is a fungus associated with allergic bronchopulmonary aspergillosis (ABPA) and other allergic diseases. Immune responses in these diseases are due to T and B cell responses. T cell activation requires both Af-specific engagement of the T-cell-receptor as well as interaction of antigen indepe...

journal_title：Clinical and experimental immunology

authors： Barrios CS,Johnson BD,D Henderson J Jr,Fink JN,Kelly KJ,Kurup VP

更新日期：2005-11-01 00:00:00

abstract：:Tuberculosis (TB) enhances human immunodeficiency virus-1 (HIV-1) activity in patients with dual HIV-1/TB infection. Therapies that control augmentations of HIV-1 activity at sites of Mycobacterium tuberculosis (MTB) infection may be useful in inhibition of viral expansion. Regulated upon activation, normal T-cell exp...

journal_title：Clinical and experimental immunology

authors： Toossi Z,Mayanja-Kizza H,Baseke J,Peters P,Wu M,Abraha A,Aung H,Okwera A,Hirsch C,Arts E

更新日期：2005-11-01 00:00:00

abstract：:To characterize the immune response following primary human hookworm infection, an adult volunteer was infected with 50 L3 larvae of Necator americanus, reinfected 27 months later and followed for a further 6 months. Clinical signs, blood picture, ex-vivo peripheral blood cytokine production (IFN-gamma, IL-5, IL-13, I...

journal_title：Clinical and experimental immunology

authors： Wright V,Bickle Q

更新日期：2005-11-01 00:00:00

abstract：:Type 1 IFN is thought to be implicated in the autoimmune process of SLE. Plasmacytoid dendric cells (DC), which are natural IFN-alpha producing cells, play a pivotal epipathogenic role in SLE. The present study was undertaken to investigate the phenotypic characteristics of peripheral blood DC in SLE patients in compa...

journal_title：Clinical and experimental immunology

authors： Migita K,Miyashita T,Maeda Y,Kimura H,Nakamura M,Yatsuhashi H,Ishibashi H,Eguchi K

更新日期：2005-10-01 00:00:00

abstract：:To investigate the possible role of tryptophan metabolism in immune regulation of primary Sjögren's syndrome (pSS) the serum concentrations of tryptophan and its metabolite kynurenine were measured by reverse-phase high-performance liquid chromatography (HPLC) in 103 patients with pSS, 56 patients with sicca symptoms ...

journal_title：Clinical and experimental immunology

authors： Pertovaara M,Raitala A,Uusitalo H,Pukander J,Helin H,Oja SS,Hurme M

更新日期：2005-10-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharides, plays an important role in the innate immune response. In this study, we investigated the role of TLR4 in the development of experimental colitis with regard to the biological actions of macrophage migration inhibitory factor (MIF) using TLR4 null ((-/...

journal_title：Clinical and experimental immunology

authors： Ohkawara T,Takeda H,Nishihira J,Miyashita K,Nihiwaki M,Ishiguro Y,Takeda K,Akira S,Iwanaga T,Sugiyama T,Asaka M

更新日期：2005-09-01 00:00:00

abstract：:Both viral effect and immune-mediated mechanism are involved in the pathogenesis of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) infection. In this study, we showed that in SARS patient sera there were autoantibodies (autoAbs) that reacted with A549 cells, the type-2 pneumocytes, and that these ...

journal_title：Clinical and experimental immunology

authors： Lin YS,Lin CF,Fang YT,Kuo YM,Liao PC,Yeh TM,Hwa KY,Shieh CC,Yen JH,Wang HJ,Su IJ,Lei HY

更新日期：2005-09-01 00:00:00

abstract：:Capsular polysaccharide from Actinobacillus actinomycetemcomitans Y4 (Y4 CP) induces bone resorption in a mouse organ culture system and osteoclast formation in mouse bone marrow cultures, as reported in previous studies. We also found that Y4 CP inhibits the release of interleukin (IL)-6 and IL-8 from human gingival ...

journal_title：Clinical and experimental immunology

authors： Iwata T,Mitani A,Ishihara Y,Tanaka S,Yamamoto G,Kikuchi T,Naganawa T,Matsumura Y,Suga T,Koide M,Sobue T,Suzuki T,Noguchi T

更新日期：2005-08-01 00:00:00

abstract：:Up to 20% of Crohn's disease (CD) patients respond poorly to glucocorticoids (GC). A product of an alternative splicing of the glucocorticoid receptor (GR) premRNA, GRbeta, may play a role as a dominant inhibitor of the glucocorticoid response. Increasing evidence suggests that inflammatory cytokines such as interleuk...

journal_title：Clinical and experimental immunology

authors： Towers R,Naftali T,Gabay G,Carlebach M,Klein A,Novis B

更新日期：2005-08-01 00:00:00

abstract：:We have reported previously that the LAD-4 monoclonal antibody (mAb) directed against a fibronectin receptor (FNR) on RL-male-1 T lymphoma cells in BALB/c mice partially inhibited their migration to the liver. In the present study, we examined the mechanism by which another anti-FNR mAb, LAD-1, exerts its antitumourig...

journal_title：Clinical and experimental immunology

authors： Ito M,Omoto S,Kato Y,Hayashi T,Mori N,Fujii YR

更新日期：2005-07-01 00:00:00

abstract：:Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/ perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms in tumour necrosis factor (TNF)-alpha and intercellular adhesion molecule-1 (ICAM-1) are associated with occurrence and/or outcome in Crohn's disease. The aim of th...

journal_title：Clinical and experimental immunology

authors： Yacyshyn BR,Schievella A,Sewell KL,Tami JA

更新日期：2005-07-01 00:00:00

abstract：:Toll-like receptors (TLRs) constitute an archetypal pattern recognition system. Their sophisticated biology underpins the ability of innate immunity to discriminate between highly diverse microbial pathogens and self. However, the remarkable progress made in describing this biology has also revealed new immunological ...

journal_title：Clinical and experimental immunology

authors： Hopkins PA,Sriskandan S

更新日期：2005-06-01 00:00:00

abstract：:Tuberculosis (TB) is usually more severe in HIV-infected patients, and the immune derangement found in co-infected patients may differ from that in each isolated disease. Following mitogen stimulation of peripheral blood mononuclear cells (PBMC), interferon (IFN)-gamma and tumour necrosis factor (TNF)-alpha production...

journal_title：Clinical and experimental immunology

authors： de Castro Cunha RM,Kallas EG,Rodrigues DS,Nascimento Burattini M,Salomao R

更新日期：2005-06-01 00:00:00

abstract：:Autoantibodies to insulin are often the first autoantibodies detected in young children with type 1 diabetes and can be present before the onset of clinical diabetes. These autoantibodies and their epitopes are, however, not well characterized. We explored the use of monoclonal antibodies and their recombinant Fab as ...

journal_title：Clinical and experimental immunology

authors： Padoa CJ,Crowther NJ,Thomas JW,Hall TR,Bekris LM,Torn C,Landin-Olsson M,Ortqvist E,Palmer JP,Lernmark A,Hampe CS

更新日期：2005-06-01 00:00:00

abstract：:Summary The interaction between stroma and blood cells in the human spleen has received little attention, despite their well-defined roles during blood cell development in bone marrow. We have reported previously that human spleen-derived fibroblasts display a differentiated myofibroblast phenotype and constitutively ...

journal_title：Clinical and experimental immunology

authors： Briard D,Azzarone B,Brouty-Boyé D

更新日期：2005-05-01 00:00:00

abstract：:YKL-40 is secreted by macrophages and neutrophils and patients with bacterial infections have elevated circulating YKL-40. The aim was to evaluate changes in plasma YKL-40 (determined by enzyme-linked immunosorbent assay (ELISA) at 0, 2, 4, 8, 24 and 32 h) in eight healthy volunteers after injection with Esherichia co...

journal_title：Clinical and experimental immunology

authors： Johansen JS,Krabbe KS,Møller K,Pedersen BK

更新日期：2005-05-01 00:00:00

abstract：:Listeria monocytogenes (Listeria) are known to grow and proliferate in the liver while a splenectomy induces host resistance against a Listeria infection despite the fact that a splenectomy inhibits the Th1 response. Therefore, the mechanism by which a splenectomy helps to prevent the growth of Listeria still remains ...

journal_title：Clinical and experimental immunology

authors： Kuranaga N,Kinoshita M,Kawabata T,Shinomiya N,Seki S

更新日期：2005-04-01 00:00:00

abstract：:The non-specific acute phase response in mice is associated with increased resistance to bacterial infection, which is critically mediated by granulocyte colony stimulating factor (G-CSF), but the behaviour of G-CSF in the human acute phase response is not known. Cardiothoracic surgery is a powerful acute phase stimul...

journal_title：Clinical and experimental immunology

authors： Noursadeghi M,Pepys MB,Gallimore R,Cohen J

更新日期：2005-04-01 00:00:00

abstract：:In patients with ANCA-associated vasculitis (AAV), CD25 expression is increased on circulating T cells. Although in animal experiments the role of CD4(+) CD25(+) T-regulatory-cells (T(reg)) in protection against autoimmunity is well established, the role of these cells in AAV is unknown. To investigate the hypothesis ...

journal_title：Clinical and experimental immunology

authors： Marinaki S,Neumann I,Kälsch AI,Grimminger P,Breedijk A,Birck R,Schmitt W,Waldherr R,Yard BA,Van Der Woude FJ

更新日期：2005-04-01 00:00:00

abstract：:An original representative of histamine-containing peptidomimetics L-glutamyl-histamine (L-Glu-Hist) was synthesized and characterized as a cytokine mimic leading to cellular responses of improved specificity. The energy-minimized 3-D conformations of L-Glu-Hist derived from its chemical structure resulted in stabiliz...

journal_title：Clinical and experimental immunology

authors： Babizhayev MA,Semiletov YA,Lul'kin YA,Sakina NL,Savel'yeva EL,Alimbarova LM,Barinskii IP

更新日期：2005-03-01 00:00:00

abstract：:While most of our understanding of immune dysfunction in dialysis patients involves alterations in CD28-CD80/86 signalling, nothing is known of CD46-mediated co-stimulation of T cells in these patients. Because C3b/C4b bind to CD46 and complement activation occurs during haemodialysis (HD), we addressed whether CD46-m...

journal_title：Clinical and experimental immunology

authors： Brinkkoetter PT,Marinaki S,Gottmann U,Fleckenstein S,Stump C,Van Der Woude FJ,Braun C,Yard BA

更新日期：2005-03-01 00:00:00

abstract：:Thyroid autoantigens require internalization and processing by antigen-presenting cells to induce immune responses. Besides pinocytosis, antigen uptake can be receptor-mediated. The mannose receptor (ManR) has a cysteine rich domain (CR) and eight carbohydrate recognition domains (CRD) that bind glycosylated proteins....

journal_title：Clinical and experimental immunology

authors： Chazenbalk GD,Pichurin PN,Guo J,Rapoport B,McLachlan SM

更新日期：2005-02-01 00:00:00

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00

abstract：:There are lines of evidence that natural killer (NK) cells are sensitive to physical and psychological stress. Alterations in the immune system including NK cells are known to differ among tissues and organs. The effect of stress on the lung immune system, however, has not been well documented in spite of the fact tha...

journal_title：Clinical and experimental immunology

authors： Kanemi O,Zhang X,Sakamoto Y,Ebina M,Nagatomi R

更新日期：2005-01-01 00:00:00

abstract：:This longitudinal study investigates the change of erythrocyte complement receptor (E-CR1) expression in patients with severe acute respiratory syndrome (SARS). Circulating E-CR1 expression was semiquantified by flow cytometric analyses in 54 SARS patients and in 212 healthy individuals as a control. Since E-CR1 expre...

journal_title：Clinical and experimental immunology

authors： Wang FS,Chu FL,Jin L,Li YG,Zhang Z,Xu D,Shi M,Wu H,Moulds JM

更新日期：2005-01-01 00:00:00

abstract：:Complement activation with formation of biologically potent mediators like C5a and the terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and tissue damage in a number of autoimmune and inflammatory conditions. A particular role for complement in the ischaemia/reperfusion injury of the...

journal_title：Clinical and experimental immunology

authors： Harboe M,Ulvund G,Vien L,Fung M,Mollnes TE

更新日期：2004-12-01 00:00:00

abstract：:The lectin pathway of complement activation is used by a collectin, mannan-binding lectin (MBL), and two ficolins, L-ficolin and H-ficolin, to opsonize microorganisms for phagocytosis. We published evidence recently that MBL insufficiency is associated with recurrent respiratory infections in childhood. We have now me...

journal_title：Clinical and experimental immunology

authors： Atkinson AP,Cedzynski M,Szemraj J,St Swierzko A,Bak-Romaniszyn L,Banasik M,Zeman K,Matsushita M,Turner ML,Kilpatrick DC

更新日期：2004-12-01 00:00:00

abstract：:Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role. Recent investigations describe an association between these immunological alterations and disturbances of the endocrine system, related most ...

journal_title：Clinical and experimental immunology

authors： Hildebrand F,Pape HC,Harwood P,Wittwer T,Krettek C,van Griensven M

更新日期：2004-11-01 00:00:00

abstract：:Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue haemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue viru...

journal_title：Clinical and experimental immunology

authors： Saito M,Oishi K,Inoue S,Dimaano EM,Alera MT,Robles AM,Estrella BD Jr,Kumatori A,Moji K,Alonzo MT,Buerano CC,Matias RR,Morita K,Natividad FF,Nagatake T

更新日期：2004-11-01 00:00:00

abstract：:Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes,...

journal_title：Clinical and experimental immunology

authors： van Haelst PL,Tervaert JW,Bijzet J,Baljé-Volkers C,May JF,Langeveld B,Gans RO

更新日期：2004-11-01 00:00:00

abstract：:Serum activity of the adenosine deaminase (ADA) isozyme, ADA2, has been reported to be elevated during various disease states. Macrophages have been suggested as the cellular source of extracellular ADA activity because they are one of the only cell types in which intracellular ADA2 activity has been measured, but ext...

journal_title：Clinical and experimental immunology

authors： Conlon BA,Law WR

更新日期：2004-10-01 00:00:00

abstract：:Interleukin 15 (IL-15) is critical for the development of human and murine natural killer (NK) cells and hepatic-derived NK T cells (NKT) in mice, and for the homeostatic maintenance of NK/NKT and CD8(+) memory T cells. The lymphocyte repertoire of an adult human liver includes significant populations of NK and NKT-li...

journal_title：Clinical and experimental immunology

authors： Golden-Mason L,Kelly AM,Doherty DG,Traynor O,McEntee G,Kelly J,Hegarty JE,O'Farrelly C

更新日期：2004-10-01 00:00:00